Endocrine Abstracts

HPA axis that plays important controlling and modulating functions in organism is also linked with insulin resistance and weight control. The number of evidences linking cortisol secretion with obesity and other metabolic complication increase, but still there is a lack of definitive results. Therefore the aim of our study was to compare adrenal function parameters between high and normal insulin resistant overweight and obese women. This retrospective analysis was performed o...

Introduction: Vitamin D, known mainly as a calcium-phosphorus homeostasis regulator, turned out to play also a significant role in the immune system modulation. Vitamin D deficiency has been reported in some autoimmune disorders. It is also suspected that polymorphisms of vitamin D-related genes comprise a risk factor for different autoimmune diseases. Therefore the aim of our study was to assess vitamin D receptor (VDR) gene FokI polymorphism in thyroid associated orbitopathy...

Introduction: Vitamin D, primarily known for its role in calcium–phosphorus homeostasis, is also a significant immunomodulatory factor. Vitamin D deficiency has been reported in some autoimmune disorders. Recently, vitamin D level in autoimmune thyroiditis (Hashimoto’s thyroiditis (HT)) has become the subject of researchers’ interest.Objectives: This study aims to assess vitamin 25-OH-D3 levels in HT patients in comparison to a control gro...

Background: TSH-suppressive therapy is widely used in treatment of thyroid differentiated carcinoma. A common consequence of therapy is subclinical hyperthyroidism which may cause dysfunction of cardiovascular system, metabolism and reduction of bone mass1. Thyroid hormones are also involved in regulation of brain function2. Therefore, it is not surprising that thyroid dysfunctions are associated with frequent comorbid cognitive dysfunctions and depressio...